Posters on the Podium

SESSION 3: Posters on the Podium

Monday • May 6, 2024 • 3:30–5:00 PM • Arizona Ballroom
Moderators: Daniela Traini, Ph.D. and Elizabeth R. Bielski, Ph.D

Poster authors chosen by the Editorial Team present their work during a fast-paced podium session.

Accelerated Stability and Aerosol Performance Assessment for a Spray Dried Nasal COVID-19 Vaccine Candidate
John Chen
Access to Advanced Health Institute
Designing mRNA Lipid Nanoparticles for Tumor Associated Macrophages: Towards Immunotherapies for the Treatment of Osteosarcoma Lung Metastases
Raneem Aldaqqa
Virginia Commonwealth University
Evaluating Published Artificial Mucus Models for Understanding Predictability of Inhaled Drug Delivery Dynamics
Nishant Shah
University of Michigan
Enhancing Nose-to-Brain Drug Delivery: A Comparative Study of Peptide Formulations Using a Multidose Nasal Spray
Chun Yuen Jerry Wong
Macquarie University
Tuning the Aerosol Delivery of the Respimat® Soft Mist Inhaler
Moritz Fleischhauer
Johannes Gutenberg-Universität Mainz
Measurement of Vapor Pressure and Viscosity of Ethanol in HFA134a, HFA152a, and HFO1234ze(E) Mixtures used in pMDIs
Swetha Chowdary Vutlapalli and Daniel Duke
Monash University
Optical Photothermal Infrared Spectroscopic Assessment of Fluticasone/Salmeterol/Lactose Co-Association in Advair Diskus® and Wixela Inhub®
Dipesh Khanal
University of Sydney

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Process Modeling for Small-Scale Manufacturing of Spray Dried Nasal Vaccine Powders
John Chen
Access to Advanced Health Institute
The Influence of Temperature and Humidity Control in Laboratory Settings on the Aerodynamic Particle Size Distribution of Soft Mist Inhalers
Sunilkumar Patel
Amneal Pharmaceuticals
Optimization of a Multidose Nasal Actuator Targeting Olfactory Region Deposition
Goncalo Farias and Charles Cazzola
Aptar Pharma
Leachables Assessment from a New Generation of pMDIs using Low Global Warming Potential Propellants and the Impact of Ethanol Filling
Pauline Faucard and Benedicte Grosjean
Aptar Pharma
Electronic Facemask to Enhance Patient Compliance
Anthony Hickey
Astartein
Pharmacokinetic Comparison of Nasal Delivered Dry Powdered Epinephrine to an Autoinjector (EpiPen®) in a Canine Model
Brian Taubenheim
Belhaven Biopharma
Development of Albuterol Sulfate Pressurized Metered Dose Inhalers using a Low Global Warming Potential Propellant 1,1-difluoroethane (HFA152a)
Lei Mao
Bespak
Development of Beclomethasone Dipropionate Pressurized Metered Dose Inhalers using a Low Global Warming Potential Propellant, 1,3,3,3-tetrafluoropropene (HFO1234ze)
Lei Mao
Bespak
Investigating the Impact of Device Design and Propellant Choice on the Aerosolization of Fluticasone Propionate Suspensions in HFA152a and HFO1234ze
Benjamin Thorne
Bespak
Using Human Factors Studies to Optimize Nozzle Geometry for Patient Interaction in the Design Development of a Unit Dose Nasal Spray
Sabrina Falloon
Bespak
Aerodynamic Characteristics of Spiriva® Handihaler® at Simulated Breathing Patterns of COPD and Healthy Subjects, and at a Constant Inhalation Flow using One Capsule per Determination
Jufang Xu
CF PharmTech
Reducing Variability in the Inhaler Testing Environment
Clair Brooks
Copley Scientific
Designing a Sustainable Ipratropium HFA-152a pMDI: Actuator Geometry Considerations
Ameet Sule
H&T Presspart
Advancing DPI Technology: A Modular Approach on Optimizing Capsule Movement for Improved Performance
Mirjam Kobler
H&T Presspart
Ellipta® Blister Device: A Re-Assembly Set of Tools for Early In Vitro Comparative Studies of a Complex Pre-Metered Dry Powder Inhaler
Irene Rossi
Harro Höfliger Verpackungsmaschinen
Development of an MDI Coated Can with a Non-PFAS Polymeric Coating
Loy Britto
Healthy Airways
Two Isn’t Always Better Than One: A Single-Actuation Salbutamol Sulfate Metered Dose Inhaler Using Low-GWP Propellant HFO-1234ze(E)
Erik Boldt and Gregory Smith
Honeywell
Understanding Leucine Encapsulation in Dry Powder Inhaler Microparticles via Surface Characterization Techniques
Lidia Santos and Claudia Costa
Hovione
Differential Permeability of Dry Solid and Aqueous Suspensions of Fluticasone Propionate Through A549 Alveolar Epithelial Cells
Alexandre Ribeiro
Hovione
Drug Load Influence on Aerodynamic Properties of High Dosage DPIs: A Case Study of an Aminoglycoside Model Drug
Maria Ines Lopes and Joao Pires
Hovione
Systemic Nasal Absorption of Amorphous Solid Dispersions: Supersaturating Systems for Fast Onset of Action of Poorly Soluble Drugs through the Nasal Mucosa
Patricia Henriques and Dina Morais
Hovione
Novel Inhaled Anti-Viral Against SARS-CoV-2: Feasibility of Developing a Nanofitin Dry Powder Formulation for Pulmonary Delivery using the ICOone Single Dose Dry Powder Inhaler
Måns Österberg Widerstrand and Jakob Samsøe
Iconovo
High-Content Image Analysis for Phenotypic Characterization of Foamy Macrophage Responses of Alveolar Macrophages to Amiodarone
Louis Scott and Ewelina Hoffman
ImmuONE
Novel Insight into the Microstructure of Fines-Only Formulations using X-ray Computed Tomography with Machine Learning
Parmesh Gajjar and Darragh Murnane
InformiX Pharma
The Impact of the Universal Spacer System on Efficiency and Reliability of Dose Delivery of Inhaled Nebulized Aerosols
Barry Clements
Inspiring Holdings Pty Ltd
Laser Diffraction Size Analysis of Products for Nasal Inhalation: A Survey of Expert Users
Jolyon Mitchell
IPAC-RS
Regulatory Topics in Nasal Product Development: Pediatrics and Reliability Expectations
Svetlana Lyapustina
IPAC-RS
Practical Considerations for Conducting Successful In Vitro Bioequivalence Studies on Inhalers
James Drake
Kindeva Drug Delivery
An Assessment of the Effect of Vacuum Crimping on Dry Powder Filled pMDI Cans
Sally Stanford
Koura
Formulation of an Intranasal Dry Powder Vaccine Candidate for Tuberculosis
Sana Hosseini and Kimberly Shepard
Lonza
Manufacturability of Intranasal Dry Powders Spray Dried from Aqueous Solutions
Neerja Zambare and Kimberly Shepard
Lonza
Impact of Vibrating Mesh Nebulization on the Physicochemical Properties of mRNA and siRNA Lipid Nanoparticle Formulations
Katrin Wiebe and Simone Carneiro
Ludwig-Maximilians-University Munich
Application of Raman Spectroscopy for Dry Powder Inhalation Formulation
Mridul Majumder
M2M Pharmaceuticals
Validation of the RS01X™ Smart Inhaler in a Clinical Setting
Dumiana Chamaon and Martijn F. Grinovero
Medisch Spectrum Twente
Effects of Low Global Warming Potential Propellants HFA152a and HFO1234ze(E) on the Morphology of Suspension Based Pressurized Metered Dose Inhaler Sprays
Daniel Duke
Monash University
Manipulation of pMDI Spray Morphology via Orifice Length Variation with Propellants HFA134a, HFA227, HFA152a and HFO1234ze(E)
Daniel Duke and Lingzhe Rao
Monash University
The Fluid Dynamics of a Dry Powder Inhaler Assisted with a Zero-Net-Mass-Flux Jet
Rina Perven
Monash University
Utilizing Physiologically-based Modeling for the Design of an Inhaled Powder Formulation of Imipenem Aimed at Maximizing the Dose Delivered to the Lung Lining Fluid
Will Ganley
Nanopharm, an Aptar Pharma Company
Comparative Assessment of Plume Velocity in pMDI Solutions: A Study using Phase Doppler Anemometry and SprayView Analysis
Will Ganley and Nuria Manzano
Nanopharm, an Aptar Pharma Company
Ultrafine siRNA-laden Aerosol Using Next Generation Nebulizer
Neil Fullarton
Nebu-Flow
Spray Dried Amorphous Epinephrine Nasal Powder for the Acute Treatment of Anaphylaxis
Jonas Sävmarker
Orexo AB
Case Studies on Reformulation of BDP MDIs using Low GWP Propellants HFO1234ze and HFA152a
Daniel Lewis
Oz-UK Limited
Aerosol Performance and Usability Evaluation of New Pediatric Facemasks for a Valved Holding Chamber
Andrea Winzen and Martin Schlun
PARItec
Inhalation and Exhalation Airflow Resistance of Valved Holding Chambers
Deborah Jones and Timothy Fallon
Proveris Scientific
Methodology for Measurement of Evaporation Fraction and Evaporation Rate: A Comparison of HFA-134a and HFA-152a pMDI Formulations
Lynn Jordan
Proveris Scientific
Examining User Breathing Patterns During Nebulization with a Guided Inhalation Maneuver
Carolina Dantas
Pulmotree Medical
Liposomal Formulation Reduces Cell Uptake of Bacteriophage in a Lung Epithelial Cell Model
Shruti Sawant
Purdue University
Impact of L-leucine on Stability and Aerosol Performance of Dry Powder Protein Formulations
Kinnari Arte
Purdue University
Assessing the Variability of In Silico Lung Deposition Predictions When Inhaling from Soft Mist Inhalers with Various Air Flow Resistances
Nicolas Buchmann
Resyca
Physicochemical and Aerodynamic Stability of Spray Dried Tigecycline Inhalation Powder for the Treatment of Pulmonary Nontuberculous Mycobacterial Infections
Sara Maloney Norcross
RTI International
Unlocking the Promise of Digital Inhalers: Insights from an In Vitro Study
Yannick Baschung
Solvias
The Anti-Microbial Peptide, H1b, for Non-Small Cell Lung Cancer Treatment: Dry Powder Formulation Development And Characterization
Alec Diorio and Alan Watts
St. John's University
Lipid-Based Spray Dried Microparticles of Monoclonal Antibodies for Inhalation
Varsha Nair and Rex Moore
The University of Texas at Austin
A Comparison of the Aerosol Dispersion of Twelve Micronized Powders
Jamie Spahn
The University of Texas at Austin
Drum Filling of Thin-Film Freeze-Dried Monoclonal Antibody Powders into a Nasal Spray System
Mike Sandoval and Alan Watts
The University of Texas at Austin
Effect of Flow Rate on Emitted Aerodynamic Particle Size Distribution from a Dry Powder Inhaler Delivering a Short-Acting Beta2 Agonist as Monotherapy
Mark Nagel
Trudell Medical International
Characterization of Spray-Dried Phospholipid Porous Particles for Inhalation Drug Delivery
Susan Boc
U.S. Food & Drug Administration
Development of an In Vitro Method for In Vivo Prediction of Regional Deposition of Nasal Powders
Nicholas Holtgrewe
U.S. Food & Drug Administration
Sensitivity of Charcoal Block PK Metrics to Differences in Regional Deposition for Budesonide and Formoterol Fumarate Dihydrate
Ross Walenga
U.S. Food & Drug Administration
Characterizing Adasuve® (Loxapine, 10 mg) Inhalation Powder Particle Size Distribution Using Laser Diffraction
Nathan Reed
U.S. Food & Drug Administration
Novel Method for Aerodynamic Particle Size Distribution Measurements from Respimat® Inhalers
Steven Chopski
U.S. Food & Drug Administration
Effects of Surfactant Coating on Levofloxacin-Loaded Nanoparticles: Impact on Physicochemical Properties and In Vitro Cell Viability of Pulmonary Cells 
Laura Oliveira Nascimento
Universidade Estadual de Campinas
Enhancing Polymeric Nanodispersions for Improved Doxycycline Efficacy Against Lung Pathogen Biofilms
Victória Soares Soeiro
Universidade Estadual de Campinas
The Use of Atomic Force Microscope-Infrared Spectroscopy to Assess Co-Localization of Fluticasone/Salmeterol/Lactose in Advair Diskus® 100/50 Formulations
Blessy Joseph
University of Alabama at Birmingham
Tandem Aerodynamic Particle Sizers Method for the Characterization of Aerosol Dynamics at Different Relative Humidities
Yiliang Jiang
University of Bristol
The Influence of Salts on Spray Dried Powder for Nasal Inhalation: Aerosol Characterization with 3D-Printed Nasal Replica
Han Cong Seow
University of Hong Kong
Optimization of Carbohydrate Excipient Ratios in Respirable Protein Powder Formulations
Grace Xia
University of Michigan
Aerosol Performance of OHet72 Nanosuspensions Nebulized into a Custom-Made Nose-Only Dosing Chamber
Alexa Beathard
University of Oklahoma Health Science Center
Tailoring of a Pramlintide Pulmonary Dry Powder for Diabetes and Obesity Treatment
Francesca Buttini
University of Parma
Effect of Ethanol Content and Actuator Orifice Diameter on the Performance of Salbutamol Sulfate pMDI Suspensions in HFO1234ze(E)
Francesca Buttini
University of Parma
Comparing Carbon Emissions for Three Dry Powder Inhaler Technologies
Francesca Buttini
University of Parma
Successful Scale-Up of a Spray Dried Formulation for Nasal Drug Delivery
Lara Penn
Upperton Pharma Solutions
Efficacy of Inhaled ALX1 in a Model of Chronic Pseudomonas Aeruginosa Infection
Mark Schoenfisch
Vast Therapeutics
Exploration of Alternative Methodologies for Spray Pattern Evaluation in a Budesonide/Formoterol Fumarate Dihydrate pMDI
Fraser Carr
Vectura
Bio-Based Plastics for Medical Devices: A Case Study
Philip Smith
Vectura
A Novel Hybrid Molecule of Melatonin and Curcumin: In Vivo Therapeutic Intervention in the Rat Model of Lung Fibrosis with Local Lung Delivery
Masahiro Sakagami
Virginia Commonwealth University
Efficient Delivery of Powder Aerosol to the Lungs of Small Animals with a New Air-Jet Dry Powder Insufflator
Rudra Pangeni
Virginia Commonwealth University
Advancements in Complete-Airway Modeling of Pharmaceutical Aerosols: Implementation of a Tracheobronchial Voluming-Filling Algorithm
Morgan Thomas
Virginia Commonwealth University
Locally Administered Gemcitabine Chemotherapy for the Treatment of Osteosarcoma Lung Metastases
Victoria Garcia
Virginia Commonwealth University
In Vivo Efficacy of Tobramycin Excipient Enhanced Growth Dry Powder Aerosol in Pseudomonas Aeruginosa Lung Infection Model
Surendra Poudel
Virginia Commonwealth University
Comparison of In Vitro Aerosol Performance and Powder Characteristics of a Synthetic Lung Surfactant Powder Aerosol Formulation Produced using Two Spray Drying Methods
Felicia Hall
Virginia Commonwealth University
Pharmaceutical Aerosol Deposition in a Stainless-Steel Version of the VCU Mouth-Throat Models
Caleb Dalton
Virginia Commonwealth University
Spray Characterization of Low Volume Air-Jet Dry Powder Inhaler Devices for the Delivery of a Synthetic Lung Surfactant Powder Formulation
Caleb Dalton
Virginia Commonwealth University
Comparison of In Vitro Aerosol Deposition by Salbutamol pMDI with Corrugated Tubing and Commercial Spacer
Patrick He
Woolcock Institute of Medical Research
In Vitro Aerosol Delivery Performance of the Zenius Prototype Inhaler
Yui Muguruma
Zenius Limited
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