Airway Geometry Variations and Disease Effects on Regional Drug Deposition
De Backer J.
Respiratory Drug Delivery 2016. Volume 1, 2016: 117-124.
Abstract:
Functional airway imaging, based on the collection of high resolution computed tomography (HRCT) scans during expiration and inspiration enable the “lung health” of patients with different disease phenotypes to be compared regionally, to disease-free “lung normal” volunteers. These images enable computation of patient-dependent image-based whole lung and regional airway parameters such as airway volume and airway resistance that provide a much more detailed description of individual lung phenotypes than typical pulmonary function testing. When coupled with computational fluid dynamic (CFD) modeling and 3-dimensional aerosol deposition imaging (single-photon emission computerized tomography (SPECT)), non-homogeneous drug deposition and high-concentration hotspots become predictable, with possible clinical consequences.
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