Solving the Particle Adhesion Paradox: Respirable Agglomerates of Micronized Drugs and Porous (Microcarrier) Particles
Weers JG, Tarara TE, Teung P, Walsh K, Rao N, Le J, Haynes A, Huang D, Miller DP.
RDD Europe 2015. Volume 1, 2015: 177-186.
Abstract:
A novel process for creating homogeneous ordered mixtures of micronized drug and small porous carrier particles is described. The process involves spray drying a co-suspension of micron-sized particles dispersed in a liquid non-solvent. Strong adhesive forces between the drug particles and carrier particles are anticipated, with the low-density ordered mixtures forming “respirable agglomerates’” with an aerodynamic size less than 5 μm. The engineered particles exhibit significant improvements in lung targeting and dose consistency relative to spheronized particles and conventional blends of micronized drug and coarse lactose.
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