DPI Formulation Development and Manufacturing

Our core particle engineering expertise through milling and/or spray drying is complemented with extensive formulation and process development, specialized relevant characterization tools that allow mechanistic understanding, and encapsulation capabilities to provide integrated respiratory product development from concept through the clinic and commercialization. More Info

Particle Engineering for Respiratory Drug Delivery

Pulmonary illness rates are increasing and respiratory diseases continue to be a leading cause of death and disability worldwide. A critical quality attribute of inhalable powders is that they are in the 1-5 micron size range for optimum deposition in the lung. This executive summary contains (1) discussion of particle engineering approaches for inhaled compounds; (2) comparison of bottom-up approaches (including spray drying, spray freeze drying, supercritical fluid technologies) vs. top-down approaches such as micronization (3) a case study of inhalable mannitol powders produced by micronization and spray drying. More Info

Engineering Approaches to Respiratory Drug Delivery - Mannitol Case Study

Spray drying and jet milling are commercially viable engineering processes for the development of respirable drug products. This summary presents a case study that explores the material and performance properties of spray-dried and jet-milled mannitol for respiratory delivery of crystalline mannitol. To learn more, please read our executive summary. More Info

Technology Selection for Dry Powder Inhaler-Based Product Development

A key motivation in pharmaceutical development is getting a product to patients quickly. There are various dry powder inhaler types, but when developing a new DPI product, using capsule-based inhalers may optimize speed to clinic and market. Using a risk-based approach that ensures the appropriate technologies are selected can be the best path to success. More Info

Webinar: Technical Considerations for Capsule-Based Inhalation Product Development

This webinar explores the technical issues that must be explored for successful development of effective capsule-based products. Key design considerations are discussed, including formulation attributes; technology selection (e.g., spray-drying, micronization); and capsule and device considerations. To learn more, please view our webinar. More Info

Webinar: Local Delivery for Treatment of Lung Cancer: Manufacturing Formulations for Dry Powder Inhaler by Spray Drying

In this webcast, we will discuss two case studies where lung cancer therapies were delivered to the lung by dry powder inhaler in a rat model and evaluated for efficacy. The results confirmed that local delivery is a promising route to treat lung cancer. More Info