Exploring Inhalation Blend Pre-Actuation Microstructure using X-Ray Computed Tomography: Properties, Processing and Performance
Gajjar P, Styliari I, Withers PJ, Murnane D.
RDD Asia 2024. Volume 1, 2024: 54-64.
Abstract:
The interaction of the patient airflow with the bulk powder, to deagglomerate the formulated product, is critical to the performance of dry powder inhalers (DPIs). Fluidization behavior and subsequent deagglomeration and aerosolization is dependent on the formulated product microstructure, and thus characterizing both the pre-actuated and post-aerosolized microstructure is an important part of bioequivalence assessments. X-ray Computed Tomography (XCT) has emerged as a suitable technique for studying the pre-actuation microstructure of inhalation powders, with its ability to characterize a powder bed without disturbance. In this article we review recent developments in XCT for characterizing pre-actuated powder microstructure, understanding the microstructure in the context of properties, processing and performance. Finally, we ask whether XCT can be truly a non-destructive technique?
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