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Pulmonary Drug Dissolution, Regional Retention and Systemic Absorption: Understanding their Interactions Through Mechanistic Modeling

B├Ąckman P, Olsson B.

Respiratory Drug Delivery 2020. Volume 1, 2020: 113-122.

Abstract:

The pharmacokinetics (PK) of fluticasone propionate (FP, when dosed from Advair Diskus) was simulated using a mechanistic computer-based model informed with: (i) physicochemical drug properties and (ii) product batch specific performance attributes (dose, dose deposition and dissolution rate). Simulated PK correlated well with observed PK providing an in-context validation of the model. The model was then used to explore how PK and lung targeting are expected to respond to changes in dissolution rate and solubility for a poorly soluble inhaled drug.

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