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Using Phase Doppler Anemometry and High Speed Imaging to Analyze MDI Spray Plume Dynamics

Versteeg HK, Hargrave G, Myatt BJ, Lewis DA, Church T, Brambilla G.

RDD Europe 2017. Volume 1, 2017: 129-142.

Abstract:

Characterization of inhalation aerosols focuses in the first instance on aerodynamic particle size, which is measured using cascade impactors. The aerosol must contain large quantities of particles in the respirable size range 1-5 μm. Deposition on impactor stages depends on the velocity of the particles as well as their size. Pressurized metered dose inhalers (pMDIs) produce very fast-moving spray plumes, so it is important to understand the dynamic nature of droplet formation processes and spray plumes. This paper presents a selection of findings from an optical diagnostics study of aerosol plumes generated by a Bespak 630 series actuator in conjunction with a series of HFA134a placebo formulations containing ethanol up to 20% w/w. Spray plume dynamics in the vicinity of the spray orifice and further downstream were characterized using phase-Doppler anemometry (PDA), high-speed imaging and particle image velocimetry (PIV). The findings demonstrate the complementary capabilities of these instruments. PDA provides simultaneous values of mean droplet size and velocity (and their associated statistics), but it is time-consuming to sample a sufficient number of locations to characterize the rapidly changing spray plume. PIV, on the other hand, provides information on entire flow fields albeit at lower spatial and temporal resolution. PIV and PDA data for the velocity of various spray plumes were found to be in good agreement, which validates both techniques. High-speed imaging also captures the overall characteristics of the plume. The diffraction limit of the optical configuration used for imaging is around 10 μm, so it is not possible to observe respirable droplets individually. However, the dynamics and trajectories of larger droplets can be studied. Larger droplets were found to be produced by highly localized atomization processes, so the resulting droplets can be easily missed or undersampled in PDA surveys.

These results suggest that further research on pMDI sprays with these combined tools will provide useful insights into the processes responsible for changes in droplet size and velocity, and can be expected to make a major contribution to improving the development of the next generation of pMDI inhalers.