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Mouth-Throat Models for Realistic In Vitro Testing - A Proposal for Debate

Olsson B, B├Ąckman P.

Respiratory Drug Delivery 2014. Volume 1, 2014: 287-294.


Recent literature data from multiple groups show that in vivo mimicking in vitro approaches are valid to predict initial total lung deposition, which has been a goal for many decades. It is now time to problematize the concept and start discussing under which circumstances initial total lung deposition may be a surrogate for pulmonary availability and thus of clinical interest. There also remain a number of important questions regarding the in vitro methodologies.

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